Corpus ID: 237091322

Characterizing the free-energy landscapes of DNA origamis

  title={Characterizing the free-energy landscapes of DNA origamis},
  author={Chak Kui Wong and Chuyan Tang and John S. Schreck and Jonathan P. K. Doye},
  • Chak Kui Wong, Chuyan Tang, +1 author J. Doye
  • Published 14 August 2021
  • Physics
We show how coarse-grained modelling combined with umbrella sampling using distancebased order parameters can be applied to compute the free-energy landscapes associated with mechanical deformations of large DNA nanostructures. We illustrate this approach for the strong bending of DNA nanotubes and the potentially bistable landscape of twisted DNA origami sheets. The homogeneous bending of the DNA nanotubes is well described by the worm-like chain model; for more extreme bending the nanotubes… Expand
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