Characterizing the emergence and persistence of drug resistant mutations in HIV-1 subtype C infections using 454 ultra deep pyrosequencing

@inproceedings{Bansode2013CharacterizingTE,
  title={Characterizing the emergence and persistence of drug resistant mutations in HIV-1 subtype C infections using 454 ultra deep pyrosequencing},
  author={Vijay B. Bansode and Grace P. McCormack and Amelia C Crampin and Bagrey M.M. Ngwira and Ram Krishna Shrestha and Neil S French and Judith R. Glynn and Simon A. A. Travers},
  booktitle={BMC Infectious Diseases},
  year={2013}
}
BackgroundThe role of HIV-1 RNA in the emergence of resistance to antiretroviral therapies (ARTs) is well documented while less is known about the role of historical viruses stored in the proviral DNA. The primary focus of this work was to characterize the genetic diversity and evolution of HIV drug resistant variants in an individual’s provirus during antiretroviral therapy using next generation sequencing.MethodsBlood samples were collected prior to antiretroviral therapy exposure and during… CONTINUE READING
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