Characterizing the dynamics of proteasome complexes by proteomics approaches.


SIGNIFICANCE The proteasome is the degradation machine of the ubiquitin-proteasome system, which is critical in controlling many essential biological processes. Aberrant regulation of proteasome-dependent protein degradation can lead to various human diseases, and general proteasome inhibitors have shown efficacy for cancer treatments. Though clinically… (More)
DOI: 10.1089/ars.2013.5815


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