Characterizing the dynamics of functionally relevant complexes of formate dehydrogenase.

@article{Bandaria2010CharacterizingTD,
  title={Characterizing the dynamics of functionally relevant complexes of formate dehydrogenase.},
  author={Jigar N. Bandaria and Samrat Dutta and Michael Walt Nydegger and William Rock and Amnon Kohen and Christopher M Cheatum},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 42},
  pages={17974-9}
}
The potential for femtosecond to picosecond time-scale motions to influence the rate of the intrinsic chemical step in enzyme-catalyzed reactions is a source of significant controversy. Among the central challenges in resolving this controversy is the difficulty of experimentally characterizing thermally activated motions at this time scale in functionally… CONTINUE READING