Characterizing the conductance underlying depolarization-induced slow current in cerebellar Purkinje cells.

@article{Kim2013CharacterizingTC,
  title={Characterizing the conductance underlying depolarization-induced slow current in cerebellar Purkinje cells.},
  author={Yu Shin Kim and Eunchai Kang and Yuichi Makino and Sungjin Park and Jung Hoon Shin and Hongjun Song and Pierre Launay and David E. J. Linden},
  journal={Journal of neurophysiology},
  year={2013},
  volume={109 4},
  pages={1174-81}
}
Brief strong depolarization of cerebellar Purkinje cells produces a slow inward cation current [depolarization-induced slow current (DISC)]. Previous work has shown that DISC is triggered by voltage-sensitive Ca influx in the Purkinje cell and is attenuated by blockers of vesicular loading and fusion. Here, we have sought to characterize the ion channel(s) underlying the DISC conductance. While the brief depolarizing steps that triggered DISC were associated with a large Ca transient, the onset… CONTINUE READING
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membrane depolarization

  • P Launay, H Cheng, S Srivatsan, R Penner, A Fleig, JP Kinet
  • 2002
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