Characterizing the behavioral effects of nerve agent-induced seizure activity in rats: increased startle reactivity and perseverative behavior.

@article{Langston2012CharacterizingTB,
  title={Characterizing the behavioral effects of nerve agent-induced seizure activity in rats: increased startle reactivity and perseverative behavior.},
  author={Jeffrey L. Langston and Linnzi K.M. Wright and Nick Connis and Lucille A. Lumley},
  journal={Pharmacology, biochemistry, and behavior},
  year={2012},
  volume={100 3},
  pages={382-91}
}
The development and deployment of next-generation therapeutics to protect military and civilian personnel against chemical warfare nerve agent threats require the establishment and validation of animal models. The purpose of the present investigation was to characterize the behavioral consequences of soman (GD)-induced seizure activity using a series of behavioral assessments. Male Sprague-Dawley rats (n=24), implanted with a transmitter for telemetric recording of encephalographic signals… CONTINUE READING

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