Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice.

@article{Yan2009CharacterizingTA,
  title={Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice.},
  author={Ping Wang Yan and Adam W. Bero and John R Cirrito and Qingli Xiao and Xiaoyan Hu and Yanli Wang and Ernesto Gonzales and David M Holtzman and Jin-Moo Lee},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 34},
  pages={10706-14}
}
Amyloid plaques are primarily composed of extracellular aggregates of amyloid-beta (Abeta) peptide and are a pathological signature of Alzheimer's disease. However, the factors that influence the dynamics of amyloid plaque formation and growth in vivo are largely unknown. Using serial intravital multiphoton microscopy through a thinned-skull cranial window in APP/PS1 transgenic mice, we found that amyloid plaques appear and grow over a period of weeks before reaching a mature size. Growth was… CONTINUE READING