Characterizing the HER2/neu Status and Metastatic Potential of Breast Cancer Stem/Progenitor Cells

Abstract

Treatment resistance, long latency, and high recurrence rates suggest that breast cancers arise from defective breast stem cells. Within cancers, subpopulations of cells will demonstrate differences in stem/progenitor potential, HER2/neu amplification, and gene expression. Related cells will be found in normal breast tissue. ER-/PR-/HER2/neu + breast cancer… (More)
DOI: 10.1245/s10434-009-0730-z

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