Characterizing the HER2/neu Status and Metastatic Potential of Breast Cancer Stem/Progenitor Cells


Treatment resistance, long latency, and high recurrence rates suggest that breast cancers arise from defective breast stem cells. Within cancers, subpopulations of cells will demonstrate differences in stem/progenitor potential, HER2/neu amplification, and gene expression. Related cells will be found in normal breast tissue. ER-/PR-/HER2/neu + breast cancer… (More)
DOI: 10.1245/s10434-009-0730-z

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