Characterizing the Conformational Landscape of Flavivirus Fusion Peptides via Simulation and Experiment

  title={Characterizing the Conformational Landscape of Flavivirus Fusion Peptides via Simulation and Experiment},
  author={Jan K. Marzinek and Rajamani Lakshminarayanan and Eunice Tze Leng Goh and Roland G. Huber and Sadhana Panzade and Chandra Shekhar Verma and Peter J. Bond},
  booktitle={Scientific reports},
Conformational changes in the envelope proteins of flaviviruses help to expose the highly conserved fusion peptide (FP), a region which is critical to membrane fusion and host cell infection, and which represents a significant target for antiviral drugs and antibodies. In principle, extended timescale atomic-resolution simulations may be used to characterize the dynamics of such peptides. However, the resultant accuracy is critically dependent upon both the underlying force field and sufficient… CONTINUE READING
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Efficacy of a Tetravalent Dengue Vaccine in Children in Latin America

  • L Villar
  • N. Engl. J. Med
  • 2014

a phase 3, randomised, observer-masked, placebo-controlled trial

  • Capeding, M. R. et al. Clinical efficacy, safety of a novel tetravalent dengue vaccine in healthy c Asia
  • Lancet 384, 1358–1365
  • 2014

A Possible Candidate for Clinical Application

  • Ichiyama, K. et al. Sulfated Polysaccharide, Curdlan Sulfate, Efficiently Prevents EntryFusion, Restricts Antibody-Dependent Enhancement of Dengue Virus Inf Vitro
  • PLoS Negl. Trop. Dis. 7, e2188
  • 2013

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