Characterizing the Altered Cellular Proteome Induced by the Stress-Independent Activation of Heat Shock Factor 1

@inproceedings{Ryno2014CharacterizingTA,
  title={Characterizing the Altered Cellular Proteome Induced
by the Stress-Independent Activation of Heat Shock Factor 1},
  author={Lisa M. Ryno and Joseph C. Genereux and Tadasuke Naito and Richard I. Morimoto and Evan T Powers and Matthew D Shoulders and R Luke Wiseman},
  booktitle={ACS chemical biology},
  year={2014}
}
The heat shock response is an evolutionarily conserved, stress-responsive signaling pathway that adapts cellular proteostasis in response to pathologic insult. In metazoans, the heat shock response primarily functions through the posttranslational activation of heat shock factor 1 (HSF1), a stress-responsive transcription factor that induces the expression of cytosolic proteostasis factors including chaperones, cochaperones, and folding enzymes. HSF1 is a potentially attractive therapeutic… CONTINUE READING
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