Characterizing proton relaxation times for metallic and magnetic layer-by-layer-coated, DNA-templated nanoparticle chains.

@article{Jaganathan2010CharacterizingPR,
  title={Characterizing proton relaxation times for metallic and magnetic layer-by-layer-coated, DNA-templated nanoparticle chains.},
  author={Hamsa Jaganathan and R. Gieseck and A. Ivanisevic},
  journal={Nanotechnology},
  year={2010},
  volume={21 24},
  pages={
          245103
        }
}
Metallic and superparamagnetic DNA-templated nanoparticle (NP) chains are examined as potential imaging agents. Proton relaxation times (T(1) and T(2)) are measured for DNA nanostructures using nuclear magnetic resonance (NMR) spectroscopy. The layer-by-layer (LBL) method was used to encapsulate the DNA-templated NP chains and demonstrated a change in proton relaxation times. Results from this study suggest that LBL-coated, DNA-templated nanostructures can serve as effective imaging agents for… Expand
16 Citations
Mechanism of proton relaxation for enzyme-manipulated, multicomponent gold-magnetic nanoparticle chains.
TLDR
The results indicate that relaxation times are dependent on the one-dimensional structure and the amount of superparamagnetic NP chains present in the multicomponent constructs. Expand
Gold–iron oxide nanoparticle chains scaffolded on DNA as potential magnetic resonance imaging agents
We present a unique nanostructure design using DNA that can serve as potential magnetic resonance imaging (MRI) agents. By attaching gold and iron oxide NPs on linear strands of DNA, NP chains areExpand
Examining MRI contrast in three-dimensional cell culture phantoms with DNA-templated nanoparticle chains.
TLDR
Results suggest that MRI contrast was significantly enhanced from NP chains compared to dispersed NPs in the basement membrane and polyelectrolyte encapsulation for NP chains produced similar relaxivity to nonencapsulated NP chains due to the enhanced cell uptake of encapsulatedNP chains. Expand
Biomedical applications based on magnetic nanoparticles:DNA interactions
Magnetic nanoparticles–DNA interactions can open up new possibilities in various biomedical applications. The interaction is based on the fundamental properties of DNA and magnetic nanoparticles.Expand
Magnetic nanowires in biomedical applications.
TLDR
The basic concepts of magnetic characteristics of nanoscale objects and the influences of aspect ratio, composition and diameter on magnetic properties of NWs are addressed and some underpinning physical principles of magnetic hyperthermia, magnetic resonance imaging (MRI) and magnetic separation (MS) have been discussed. Expand
Magnetic nanoparticles–DNA interactions: design and applications of nanobiohybrid systems
Mechanisms of interaction between nucleic acid molecules and magnetic nanoparticles and methods of their conjugation in order to develop functional nanostructures are considered. The properties ofExpand
Shape matters: synthesis and biomedical applications of high aspect ratio magnetic nanomaterials.
TLDR
This review describes the two main synthetic routes for the preparation of anisotropic magnetic nanomaterials: direct synthesis and assembly methods (in which the high aspect ratio is achieved by assembly from individual building blocks). Expand
Surface design of magnetic nanoparticles for stimuli-responsive cancer imaging and therapy.
TLDR
Stimuli-responsive ligands, rationally designed to interact with various physicochemical aspects, can improve the performance of MNPs in cancer-targeted imaging and therapy. Expand
A DNA-Assembled Fe3O4@Ag Nanorod in Silica Matrix for Cholesterol Biosensing
A novel nanocomposite having DNA-assembled Fe3O4@Ag nanorods in silica matrix has been proposed for fabrication of bienzymatic cholesterol nanobiosensor. Cholesterol oxidase and horseradishExpand
Role of functionalization: strategies to explore potential nano-bio applications of magnetic nanoparticles
Advances in nanotechnology enable the production of magnetic nanoparticles (MNPs) with specific morphologies and the tailoring of their surfaces in order to manipulate their characteristics to suitExpand
...
1
2
...

References

SHOWING 1-10 OF 63 REFERENCES
DNA-templated magnetic nanowires with different compositions: fabrication and analysis.
TLDR
The structure and magnetic properties of different types of templated wires are compared in this study and the results with respect to the wire properties were correlated with those determined from the bulk properties of the nanoparticles and with the properties ofThe bulk DNA. Expand
DNA-Linked Metal Nanosphere Materials: Structural Basis for the Optical Properties
The structural basis for the aggregation-induced optical properties of colloidal gold nanosphere aggregates is examined by means of electrodynamics calculations. Recently developed methods forExpand
Synthesis of superparamagnetic nanotubes as MRI contrast agents and for cell labeling.
TLDR
The synthesis and characterization of magnetic nanotubes (MNTs) showed promising results as a MRI contrast agent with high NMR relaxivities, little cytotoxicity and high cell-labeling efficiency. Expand
Circular dichroism study of the mechanism of formation of DNA templated nanowires.
TLDR
The mechanism used in the formation of DNA templated nanowires is investigated through circular dichroism (CD) spectroscopy and information on the mode of nanoparticle binding and DNA helix alterations are explored based upon the results. Expand
Linear assemblies of magnetic nanoparticles as MRI contrast agents.
TLDR
The potential use of polyelectrolyte stabilized magnetite nanoparticles as contrast agents is shown by measuring their MR response in live rats and the new magnetic fluids have demonstrated good biocompatibility and potential for in vivo MRI diagnostics. Expand
Palladium nanoparticle-controlled growth of magnetic cobalt nanowires on DNA templates
Abstract We report a new method to fabricate magnetic Co nanowires through the control of 1–3 nm Pd nanoparticles pre-formed on DNA templates. This method effectively limits undesirable deposition inExpand
Magnetotransport of One-Dimensional Chains of CoFe2O4 Nanoparticles Ordered along DNA
We have investigated the magnetotransport properties of 5 nm CoFe 2 O 4 nanoparticles aligned into one-dimensional chains using a DNA guide. The chemically synthesized particles were capped with aExpand
Electrostatic assembly of CTAB-capped silver nanoparticles along predefined λ-DNA template
Abstract Cetyltrimethylammonium bromide (CTAB)-capped positively-charged silver nanoparticles synthesized in water–ethanol system was electrostatic assembled on predefined aligned λ-DNA template.Expand
Magnetic nanoparticle assemblies on denatured DNA show unusual magnetic relaxivity and potential applications for MRI.
TLDR
Denatured herring sperm DNA acts as a template for the preparation of magnetic nanowires, forming stable aqueous suspensions, which exhibit unprecedentedly high relaxivity at low field, suggesting that the material may be a potentially useful reagent for MRI. Expand
Controlled Assembly of Monolayer-Protected Gold Clusters by Dissolved DNA
One-dimensional chains of gold nanoparticles coated with cationic trimethyl(mercaptoundecyl)ammonium (TMA) monolayers have been electrostatically assembled along DNA molecules in solution by carefulExpand
...
1
2
3
4
5
...