Characterizing microbiota-independent effects of oligosaccharides on intestinal epithelial cells: insight into the role of structure and size

@inproceedings{Akbari2017CharacterizingME,
  title={Characterizing microbiota-independent effects of oligosaccharides on intestinal epithelial cells: insight into the role of structure and size},
  author={Peyman Akbari and Johanna Fink-Gremmels and Rianne H. A. M. Willems and Elisabetta Difilippo and H A Schols and Margriet H. C. Schoterman and Johan Garssen and Saskia Braber},
  booktitle={European journal of nutrition},
  year={2017}
}
PURPOSE The direct effects of galacto-oligosaccharides (GOS), including Vivinal® GOS syrup (VGOS) and purified Vivinal® GOS (PGOS), on the epithelial integrity and corresponding interleukin-8 (IL-8/CXCL8) release were examined in a Caco-2 cell model for intestinal barrier dysfunction. To investigate structure-activity relationships, the effects of individual DP fractions of VGOS were evaluated. Moreover, the obtained results with GOS were compared with Caco-2 monolayers incubated with fructo… CONTINUE READING
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References

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Showing 1-10 of 38 references

In vitro fermentation of galacto-oligosaccharides and its specific size-fractions using non-treated and amoxicillin-treated human inoculum

SE Ladirat, HA Schols, +3 authors H Gruppen
Bioact Carbohydr Dietary Fibre • 2014
View 5 Excerpts
Highly Influenced

Galacto-oligosaccharides exert a protective effect against heat stress in a Caco-2 cell model

S Varasteh, S Braber, J Garssen, J Fink-Gremmels
J Funct Foods • 2015

Immunological properties of inulin-type fructans.

Critical reviews in food science and nutrition • 2015
View 1 Excerpt

The functional biology of human milk oligosaccharides.

Early human development • 2015
View 1 Excerpt

Deoxynivalenol: a trigger for intestinal integrity breakdown.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2014
View 3 Excerpts

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