Characterizing interspecies uncertainty using data from studies of anti-neoplastic agents in animals and humans.

@article{Price2008CharacterizingIU,
  title={Characterizing interspecies uncertainty using data from studies of anti-neoplastic agents in animals and humans.},
  author={Paul S. Price and Russell E Keenan and Jeffrey C Swartout},
  journal={Toxicology and applied pharmacology},
  year={2008},
  volume={233 1},
  pages={64-70}
}
For most chemicals, the Reference Dose (RfD) is based on data from animal testing. The uncertainty introduced by the use of animal models has been termed interspecies uncertainty. The magnitude of the differences between the toxicity of a chemical in humans and test animals and its uncertainty can be investigated by evaluating the inter-chemical variation in the ratios of the doses associated with similar toxicological endpoints in test animals and humans. This study performs such an evaluation… CONTINUE READING

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