Characterizing inactive ribosomes in translational profiling.

@article{Liu2016CharacterizingIR,
  title={Characterizing inactive ribosomes in translational profiling.},
  author={Botao Liu and Shu-Bing Qian},
  journal={Translation},
  year={2016},
  volume={4 1},
  pages={
          e1138018
        }
}
The broad impact of translational regulation has emerged explosively in the last few years in part due to the technological advance in genome-wide interrogation of gene expression. During mRNA translation, the majority of actively translating ribosomes exist as polysomes in cells with multiple ribosomes loaded on a single transcript. The importance of the monosome, however, has been less appreciated in translational profiling analysis. Here we report that the monosome fraction isolated by… CONTINUE READING
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