Characterizing amyloid-beta protein misfolding from molecular dynamics simulations with explicit water

@article{Lee2011CharacterizingAP,
  title={Characterizing amyloid-beta protein misfolding from molecular dynamics simulations with explicit water},
  author={Chewook Lee and Sihyun Ham},
  journal={Journal of computational chemistry},
  year={2011},
  volume={32 2},
  pages={349-55}
}
Extracellular deposition of amyloid-beta (Aβ) protein, a fragment of membrane glycoprotein called β-amyloid precursor transmembrane protein (βAPP), is the major characteristic for the Alzheimer's disease (AD). However, the structural and mechanistic information of forming Aβ protein aggregates in a lag phase in cell exterior has been still limited. Here, we have performed multiple all-atom molecular dynamics simulations for physiological 42-residue amyloid-beta protein (Aβ42) in explicit water… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…