Corpus ID: 115137457

Characterizing Iron transporters in Plasmodium species Aparajita Lahree 2015

  title={Characterizing Iron transporters in Plasmodium species Aparajita Lahree 2015},
  author={DA Vida and Aparajita Lahree and Maria M. Mota and Marija S. Markovi{\'c}},


A comprehensive evaluation of rodent malaria parasite genomes and gene expression
The greatly improved genome assemblies of PbA and PcAS, newly sequenced the virulent parasite P. yoelii YM genome, sequenced additional RMP isolates/lines and have characterized genotypic diversity within RMP species. Expand
Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport
The crystal structure of Staphylococcus capitis DMT, a close prokaryotic homolog of the SLC11 family, is determined and reveals a conserved mechanism for transition-metal ion selectivity within the S LC11 family. Expand
Influence of host iron status on Plasmodium falciparum infection
A large body of clinical and epidemiological evidence has accumulated which clearly demonstrates that host iron deficiency is protective against falciparum malaria and that hostIron supplementation may increase the risk of malaria. Expand
Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures
Evidence is obtained that exposure to an inhibitor of histone modification enzymes implicated in epigenetic control of gene expression induces an accelerated rate of hypnozoite activation, and may enable investigations of hyp nozoite biology and the search for compounds that killhypnozoites or disrupt their quiescence. Expand
Review on iron and its importance for human health
The latest progress in studies of iron metabolism and bioavailability is discussed, and the current understanding of human iron requirement and consequences and causes of iron deficiency is discussed. Expand
Transport proteins of parasitic protists and their role in nutrient salvage
The current knowledge on transporters from parasitic protists is summarized and commonalities and differences in the transporter repertoires of different parasitic species are highlighted, with particular focus on characterized transporter that act at the host-pathogen interface. Expand
ZIPCO, a putative metal ion transporter, is crucial for Plasmodium liver-stage development
This is the first report of a ZIP protein having a crucial role in Plasmodium liver‐stage development, as well as the first metal ion transporter identified in PlAsmodium pre‐erythrocytic stages. Expand
Expression in yeast links field polymorphisms in PfATP6 to in vitro artemisinin resistance and identifies new inhibitor classes.
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Hemoglobinopathies: Slicing the Gordian Knot of Plasmodium falciparum Malaria Pathogenesis
Hemoglobinopathies slice the “Gordian knot” of host and parasite interactions to confer malaria protection, and offer a translational model to identify the most critical mechanisms of P. falciparum pathogenesis. Expand
Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins.
Recent work has shed new light on how the malaria parasite deals with hemoglobin breakdown products and on the role of iron as a mediator of the action of the antimalarial drug, artemisinin. Expand