Characterizing Human Stem Cell–derived Sensory Neurons at the Single-cell Level Reveals Their Ion Channel Expression and Utility in Pain Research

@inproceedings{Young2014CharacterizingHS,
  title={Characterizing Human Stem Cell–derived Sensory Neurons at the Single-cell Level Reveals Their Ion Channel Expression and Utility in Pain Research},
  author={Gareth T. Young and Alex Gutteridge and Heather DE Fox and Anna L. Wilbrey and Lishuang Cao and Lily Cho and Adam R Brown and Caroline Louise Benn and Laura R Kammonen and Julia H Friedman and Magda Bictash and P. T. Whiting and James G Bilsland and Edward B. Stevens},
  booktitle={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2014}
}
The generation of human sensory neurons by directed differentiation of pluripotent stem cells opens new opportunities for investigating the biology of pain. The inability to generate this cell type has meant that up until now their study has been reliant on the use of rodent models. Here, we use a combination of population and single-cell techniques to perform a detailed molecular, electrophysiological, and pharmacological phenotyping of sensory neurons derived from human embryonic stem cells… CONTINUE READING
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Pharmacological characterisation of ligandand voltage - gated ion channels expressed in human iPSCderived forebrain neurons

S Park, KS Lee, +3 authors KC Wang
Psychopharmacology ( Berl ) • 2014

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