Characterizations of the unusual dissociation properties of melanotropin peptides from the melanocortin receptor, hMC1R.

@article{HaskellLuevano1996CharacterizationsOT,
  title={Characterizations of the unusual dissociation properties of melanotropin peptides from the melanocortin receptor, hMC1R.},
  author={Carrie Haskell-Luevano and Hiroshi Miwa and Chris Dickinson and Mac E. Hadley and Victor J. Hruby and T Yamada and Ira Gantz},
  journal={Journal of medicinal chemistry},
  year={1996},
  volume={39 2},
  pages={432-5}
}
Variation in the degree of prolonged (residual) biological activity of the melanotropin peptides alpha-MSH (alpha-melanocyte-stimulating hormone, Ac-Ser-Tyr-Met-Glu- His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2) and the superpotent analogues [Nle4,DPhe7]alpha-MSH (MT-I) and Ac-[Nle4,Asp5,DPhe7,Lys10]alpha-MSH(4-10-NH2 (MT-II) has stimulated considerable interest regarding this biological phenomena. We have examined the differences in their relative dissociation rates from the melanocortin receptor… CONTINUE READING