Characterizations of four monoclonal antibodies against M2 protein ectodomain of influenza A virus.

@article{Fu2009CharacterizationsOF,
  title={Characterizations of four monoclonal antibodies against M2 protein ectodomain of influenza A virus.},
  author={Tong-Ming Fu and Daniel C. Freed and Melanie S. Horton and Jiang Fan and Michael P. Citron and Joseph G. Joyce and Victor M. Garsky and Danilo R. Casimiro and Qinjian Zhao and John Shiver and Xiaoping Liang},
  journal={Virology},
  year={2009},
  volume={385 1},
  pages={218-26}
}
M2 protein of influenza A virus has been implicated as a target for vaccines with broad cross-strain coverage. Studies in small animal models have shown that antibody responses induced by 23-mer M2 peptide vaccines can provide protection against influenza A virus challenge. To study antiviral mechanisms of Merck M2-OMPC conjugate vaccine, we generated and characterized four M2 peptide-specific monoclonal antibodies (mAbs). Here we demonstrated that the protection by our M2 mAbs is independent… CONTINUE READING

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