Characterization with [3H]quisqualate of group I metabotropic glutamate receptor subtype in rat central and peripheral excitable tissues

@article{Hinoi2001CharacterizationW,
  title={Characterization with [3H]quisqualate of group I metabotropic glutamate receptor subtype in rat central and peripheral excitable tissues},
  author={Eiichi Hinoi and Kiyokazu Ogita and Yutaka Takeuchi and Hiroshi Ohashi and Takaharu Maruyama and Yukio Yoneda},
  journal={Neurochemistry International},
  year={2001},
  volume={38},
  pages={277-285}
}
Radioligand binding studies were performed to label metabotropic glutamate receptor (mGluR) in rat brain synaptic membranes using [3H]quisqualic acid (QA) synthesized in our laboratory as a radioligand. In the presence of ionotropic glutamate receptor (iGluR) agonists, including N-methyl-D-aspartic (NMDA), DL-alpha-amino-3-hydroxy-5-methylisoxasole-4-propionic (AMPA) and kainic acids (KA), at concentrations maximally effective in displacing each receptor binding, the agonists for group I mGluR… Expand
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