Characterization of yeast Vps33p, a protein required for vacuolar protein sorting and vacuole biogenesis.

@article{Banta1990CharacterizationOY,
  title={Characterization of yeast Vps33p, a protein required for vacuolar protein sorting and vacuole biogenesis.},
  author={Lois M. Banta and Thomas A. Vida and Paul Herman and Scott D Emr},
  journal={Molecular and cellular biology},
  year={1990},
  volume={10 9},
  pages={4638-49}
}
vps33 mutants missort and secrete multiple vacuolar hydrolases and exhibit extreme defects in vacuolar morphology. Toward a molecular understanding of the role of the VPS33 gene in vacuole biogenesis, we have cloned this gene from a yeast genomic library by complementation of a temperature-sensitive vps33 mutation. Gene disruption demonstrated that VPS33 was not essential but was required for growth at high temperatures. At the permissive temperature, vps33 null mutants exhibited defects in… CONTINUE READING

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