Characterization of vps33+, a gene required for vacuolar biogenesis and protein sorting in Schizosaccharomyces pombe.

@article{Iwaki2003CharacterizationOV,
  title={Characterization of vps33+, a gene required for vacuolar biogenesis and protein sorting in Schizosaccharomyces pombe.},
  author={Tomoko Iwaki and Fumi Osawa and Masayuki Onishi and Takako Koga and Yasuko Fujita and Akira Hosomi and Naotaka Tanaka and Yasuhisa Fukui and Kaoru Takegawa},
  journal={Yeast},
  year={2003},
  volume={20 10},
  pages={845-55}
}
From the fission yeast Schizosaccharomyces pombe we have identified and deleted vps33, a gene encoding a homologue of VPS33, which is required for vacuolar biogenesis in S. cerevisiae cells. When the vps33(+) gene is disrupted, Sz. pombe strains are temperature-sensitive for growth and contain numerous small vesicular structures stained with FM4-64 in the cells. Deletion of the Sz. pombe vps33(+) gene results in pleiotropic phenotypes consistent with the absence of normal vacuoles, including… CONTINUE READING

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