Characterization of vasopressin-mediated GSH efflux from Hep G2 cells: significance of protein kinase C.

@article{Liu1993CharacterizationOV,
  title={Characterization of vasopressin-mediated GSH efflux from Hep G2 cells: significance of protein kinase C.},
  author={Jennifer H.-Y. Liu and Chu Sato and T Takano and Fumiaki Marumo},
  journal={Life sciences},
  year={1993},
  volume={52 14},
  pages={
          1217-23
        }
}
Vasopressin stimulated GSH efflux from Hep G2 cells. The maximal effect was observed at 10nM. Pretreatment with pertussis toxin or cholera toxin for 18 hr increased GSH efflux. Vasopressin-mediated GSH efflux was observed even in the cells pretreated with those compounds. Dibutyryl-cAMP or dibutyryl-cGMP enhanced GSH efflux although an additive effect of vasopressin was not observed. Glucagon and a phorbol ester independently increased GSH efflux while both compounds decreased the effect of… CONTINUE READING