Characterization of vacuolar transport of the endogenous alkaloid berberine in Coptis japonica.

@article{Otani2005CharacterizationOV,
  title={Characterization of vacuolar transport of the endogenous alkaloid berberine in Coptis japonica.},
  author={Mihoko Otani and Nobukazu Shitan and Kyoko Sakai and Enrico Martinoia and Fumihiko Sato and Kazufumi Yazaki},
  journal={Plant physiology},
  year={2005},
  volume={138 4},
  pages={1939-46}
}
Alkaloids comprise one of the largest groups of plant secondary metabolites. Many of them exhibit strong biological activities, and, in most cases, they are accumulated in the central vacuole of alkaloid-producing plants after synthesis. However, the mechanisms involved in alkaloid transport across the tonoplast are only poorly understood. In this study, we analyzed the vacuolar transport mechanism of an isoquinoline alkaloid, berberine, which is produced and accumulated in the vacuole of… CONTINUE READING