Characterization of urinary sulfatides in metachromatic leukodystrophy using electrospray ionization-tandem mass spectrometry.

@article{Whitfield2001CharacterizationOU,
  title={Characterization of urinary sulfatides in metachromatic leukodystrophy using electrospray ionization-tandem mass spectrometry.},
  author={Phillip D. Whitfield and Peter C. Sharp and Dallas W. Johnson and Paul T. Nelson and Peter J. Meikle},
  journal={Molecular genetics and metabolism},
  year={2001},
  volume={73 1},
  pages={30-7}
}
Metachromatic leukodystrophy is an inherited disorder characterized by a deficiency of the lysosomal enzyme arylsulfatase A and the subsequent accumulation of sulfatide in neural and visceral tissues. Clinical diagnosis is usually confirmed by in vitro analysis of arylsulfatase A activity, but may be complicated in cases of arylsulfatase A pseudodeficiency… CONTINUE READING