Characterization of unprocessed insulin proreceptors in COS 7 cells transfected with cDNA with Arg735----Ser735 point mutation at the cleavage site.

Abstract

We previously reported on patients with severe insulin resistance due to unprocessed insulin proreceptors. A structural change of the cleavage site from Arg-Lys-Arg-Arg to Arg-Lys-Arg-Ser due to G----T point mutation appeared to be the cause for failure to process the proreceptors. To determine whether the mutation of insulin proreceptors at the cleavage… (More)

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Cite this paper

@article{Sugibayashi1992CharacterizationOU, title={Characterization of unprocessed insulin proreceptors in COS 7 cells transfected with cDNA with Arg735----Ser735 point mutation at the cleavage site.}, author={M. Sugibayashi and Yuko Shigeta and Hiroshi Teraoka and Maiko Kobayashi}, journal={Metabolism: clinical and experimental}, year={1992}, volume={41 8}, pages={820-6} }