Corpus ID: 20300893

Characterization of type I 5 alpha-reductase activity in DU145 human prostatic adenocarcinoma cells.

@article{Kaefer1996CharacterizationOT,
  title={Characterization of type I 5 alpha-reductase activity in DU145 human prostatic adenocarcinoma cells.},
  author={M. Kaefer and J. Audia and N. Bruchovsky and R. Goode and K. Hsiao and I. Leibovitch and J. Krushinski and C. Lee and C. Steidle and D. Sutkowski and B. Neubauer},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={1996},
  volume={58 2},
  pages={
          195-205
        }
}
The conversion of testosterone (T) to dihydrotestosterone (DHT) has been demonstrated to be catalysed by at least two isoforms of human steroid 5 alpha-reductase, designated types I and II. Type II 5 alpha-reductase expression predominates in human accessory sex tissues, localized to the fibromuscular stromal compartment. The type I isoform predominates in skin, prostatic epithelia and, to a lesser extent, in prostatic fibromuscular stroma. The significance of the type I isoform to prostatic… Expand
Characterization of a novel androgen-sensitive, prostate-specific antigen-producing prostatic carcinoma xenograft: LuCaP 23.
  • W. Ellis, R. Vessella, +5 authors P. Lange
  • Medicine
  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 1996
Acquisition of Androgen Independence by Human Prostate Epithelial Cells during Arsenic-Induced Malignant Transformation
Expression profiles of differentially expressed genes affecting fecundity in goat ovarian tissues.