Characterization of two protein kinases from Schizosaccharomyces pombe involved in the regulation of DNA repair.

@article{Dhillon1994CharacterizationOT,
  title={Characterization of two protein kinases from Schizosaccharomyces pombe involved in the regulation of DNA repair.},
  author={N. P. S. Dhillon and Merl F. Hoekstra},
  journal={The EMBO journal},
  year={1994},
  volume={13 12},
  pages={2777-88}
}
We have identified two novel genes designated hhp1+ and hhp2+ in the fission yeast Schizosaccharomyces pombe. The hhp1+ and hhp2+ genes encode two closely related protein kinases that share significant sequence identities with Hrr25p from Saccharomyces cerevisiae. Characterization of strains harboring single and double mutations in the hhp+ genes reveals DNA repair defects in these cells. Schizosaccharomyces pombe strains lacking either or both Hhp activities reveal differences in their ability… CONTINUE READING

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