Characterization of two patched receptors for the vertebrate hedgehog protein family.

@article{Carpenter1998CharacterizationOT,
  title={Characterization of two patched receptors for the vertebrate hedgehog protein family.},
  author={D. Carpenter and D. Stone and J. Brush and A. Ryan and M. Armanini and G. Frantz and A. Rosenthal and F. D. de Sauvage},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 23},
  pages={
          13630-4
        }
}
The multitransmembrane protein Patched (PTCH) is the receptor for Sonic Hedgehog (Shh), a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. Current models suggest that binding of Shh to PTCH prevents the normal inhibition of the seven-transmembrane-protein Smoothened (SMO) by PTCH. According to this model, the inhibition of SMO signaling is relieved after mutational inactivation of PTCH in the basal cell nevus syndrome. Recently, PTCH2, a molecule with… Expand
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