Characterization of two patched receptors for the vertebrate hedgehog protein family.

@article{Carpenter1998CharacterizationOT,
  title={Characterization of two patched receptors for the vertebrate hedgehog protein family.},
  author={Daniel D. Carpenter and Donna Marie Stone and Jennifer Brush and Andy Ryan and Mark P. Armanini and Gretchen Frantz and Andr{\'e} Rosenthal and Frederic J de Sauvage},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 23},
  pages={
          13630-4
        }
}
  • Daniel D. Carpenter, Donna Marie Stone, +5 authors Frederic J de Sauvage
  • Published in
    Proceedings of the National…
    1998
  • Biology, Medicine
  • The multitransmembrane protein Patched (PTCH) is the receptor for Sonic Hedgehog (Shh), a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. Current models suggest that binding of Shh to PTCH prevents the normal inhibition of the seven-transmembrane-protein Smoothened (SMO) by PTCH. According to this model, the inhibition of SMO signaling is relieved after mutational inactivation of PTCH in the basal cell nevus syndrome. Recently, PTCH2, a molecule with… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 134 CITATIONS, ESTIMATED 57% COVERAGE

    Regulators of Shh Signaling in Limb Patterning and Development

    VIEW 18 EXCERPTS
    CITES BACKGROUND & RESULTS
    HIGHLY INFLUENCED

    Mutational Analysis of Hedgehog Signaling Pathway Genes in Human Malignant Mesothelioma

    VIEW 6 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    SONIC HEDGEHOG – A MORPHOGEN WITH THERAPEUTIC IMPORTANCE

    VIEW 5 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    0331 Desert hedgehog-patched2 expression in peripheral nerves during wallerian degeneration and regeneration

    VIEW 7 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    A Molecular Fingerprint for Medulloblastoma 1

    VIEW 8 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    - 08-07 Hedgehog Signaling in Cancer

    VIEW 4 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    FILTER CITATIONS BY YEAR

    1997
    2020

    CITATION STATISTICS

    • 23 Highly Influenced Citations