Characterization of two novel pyrogenic toxin superantigens made by an acute rheumatic fever clone of Streptococcus pyogenes associated with multiple disease outbreaks.

@article{Smoot2002CharacterizationOT,
  title={Characterization of two novel pyrogenic toxin superantigens made by an acute rheumatic fever clone of Streptococcus pyogenes associated with multiple disease outbreaks.},
  author={Laura M Smoot and John K McCormick and James C Smoot and Nancy P. Hoe and Ian Strickland and R. Langton Cole and Kent D. Barbian and Cathleen A. Earhart and Douglas H. Ohlendorf and L George Veasy and Harry Raymond Hill and Donald Y. M. Leung and Patrick Schlievert and James M. Musser},
  journal={Infection and immunity},
  year={2002},
  volume={70 12},
  pages={7095-104}
}
The pathogenesis of acute rheumatic fever (ARF) is poorly understood. We identified two contiguous bacteriophage genes, designated speL and speM, encoding novel inferred superantigens in the genome sequence of an ARF strain of serotype M18 group A streptococcus (GAS). speL and speM were located at the same genomic site in 33 serotype M18 isolates, and no nucleotide sequence diversity was observed in the 33 strains analyzed. Furthermore, the genes were absent in 13 non-M18 strains tested. These… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Similar Papers

Loading similar papers…