Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR.

Abstract

We report here the isolation and characterization of two proteins, NFAR-1 and -2, which were isolated through their ability to interact with the dsRNA-dependent protein kinase, PKR. The NFAR proteins, of 90 and 110 kDa, are derived from a single gene through alternative splicing and are evolutionarily conserved nuclear phosphoproteins that interact with… (More)

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@article{Saunders2001CharacterizationOT, title={Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR.}, author={Laura R. Saunders and Darren J. Perkins and Siddarth Balachandran and Robin Michaels and Rochelle Ford and Akila Mayeda and Glen N Barber}, journal={The Journal of biological chemistry}, year={2001}, volume={276 34}, pages={32300-12} }