Characterization of two distinct modes of drug binding to human intestinal fatty acid binding protein.

@article{Patil2014CharacterizationOT,
  title={Characterization of two distinct modes of drug binding to human intestinal fatty acid binding protein.},
  author={Rahul T Patil and Aisha Laguerre and Jerome Wielens and Stephen J. Headey and Martin L Williams and Maria L. Hughes and Biswaranjan Mohanty and Christopher J. H. Porter and Martin J Scanlon},
  journal={ACS chemical biology},
  year={2014},
  volume={9 11},
  pages={
          2526-34
        }
}
The aqueous cytoplasm of cells poses a potentially significant barrier for many lipophilic drugs to reach their sites of action. Fatty acid binding proteins (FABPs) bind to poorly water-soluble fatty acids (FAs) and lipophilic compounds and facilitate their intracellular transport. Several structures of FA in complex with FABPs have been described, but data describing the binding sites of other lipophilic ligands including drugs are limited. Here the environmentally sensitive fluorophores, 1… CONTINUE READING