Characterization of two distinct liver progenitor cell subpopulations of hematopoietic and hepatic origins.

@article{Corcelle2006CharacterizationOT,
  title={Characterization of two distinct liver progenitor cell subpopulations of hematopoietic and hepatic origins.},
  author={V. Corcelle and Bruno Stieger and Asllan Gjinovci and Claes B Wollheim and Benoit R Gauthier},
  journal={Experimental cell research},
  year={2006},
  volume={312 15},
  pages={2826-36}
}
Despite extensive studies, the hematopoietic versus hepatic origin of liver progenitor oval cells remains controversial. The aim of this study was to determine the origin of such cells after liver injury and to establish an oval cell line. Rat liver injury was induced by subcutaneous insertion of 2-AAF pellets for 7 days with subsequent injection of CCl(4). Livers were removed 9 to 13 days post-CCl(4) treatment. Immunohistochemistry was performed using anti-c-kit, OV6, Thy1, CK19, AFP, vWF and… CONTINUE READING