Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2.

@article{Chen2004CharacterizationOT,
  title={Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2.},
  author={H Chen and Ralf M. Luche and Bo Wei and Nicholas K. Tonks},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 40},
  pages={41404-13}
}
Dual specificity phosphatases (DSPs) are members of the protein-tyrosine phosphatase superfamily that dephosphorylate both phosphotyrosine and phosphoserine/threonine residues in vitro. Many DSPs have been found to play important roles in various aspects of cellular function and to be involved in human disease. We have identified a gene located on human chromosome 10q22.2, which utilizes alternative open reading frames (ORFs) to encode the following two distinct DSPs: the previously described… CONTINUE READING
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