Characterization of two avian MHC-like genes reveals an ancient origin of the CD1 family.

  title={Characterization of two avian MHC-like genes reveals an ancient origin of the CD1 family.},
  author={Marcia Madsen Miller and Carren Wang and Emilio Parisini and Ricardo D Coletta and Ronald M. Goto and Stella Yu-Chien Lee and Duarte C Barral and Maria A Townes and Carme Roura-Mir and Heide L. Ford and Michael B Brenner and Christopher C. Dascher},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 24},
Many of the genes that comprise the vertebrate adaptive immune system are conserved across wide evolutionary time scales. Most notably, homologs of the mammalian MHC gene family have been found in virtually all jawed vertebrates, including sharks, bony fishes, reptiles, and birds. The CD1 family of antigen-presenting molecules are related to the MHC class I family but have evolved to bind and present lipid antigens to T cells. Here, we describe two highly divergent nonclassical MHC class I… CONTINUE READING


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Publications referenced by this paper.

Host Response Mechanisms in Infectious Disease, ed

  • C. C. Dascher, M. B. Brenner
  • Herwald, H. (Karger, Basel),
  • 2003

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