Characterization of two age-induced intracisternal A-particle-related transcripts in the mouse liver. Transcriptional read-through into an open reading frame with similarities to the yeast ccr4 transcription factor.

@article{Puech1997CharacterizationOT,
  title={Characterization of two age-induced intracisternal A-particle-related transcripts in the mouse liver. Transcriptional read-through into an open reading frame with similarities to the yeast ccr4 transcription factor.},
  author={A Puech and Anne Dupressoir and M P Loireau and Marie Genevi{\`e}ve Mattei and Thierry Heidmann},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 9},
  pages={
          5995-6003
        }
}
Intracisternal A-particle (IAP) sequences are endogenous retrovirus-like elements present at 1,000 copies in the mouse genome. We had previously identified IAP-related transcripts of unusual size (6 and 10 kilobases (kb)), which are observed exclusively in the liver of the aging mouse. In this report, using cDNA libraries that we have constructed from the liver mRNAs of an aged DBA/2 mouse, we have cloned and entirely sequenced the corresponding cDNAs. Both are initiated within the 5' long… CONTINUE READING

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