Characterization of tumors produced by signal peptide-basic fibroblast growth factor-transformed cells.

@article{Rogelj1989CharacterizationOT,
  title={Characterization of tumors produced by signal peptide-basic fibroblast growth factor-transformed cells.},
  author={S Rogelj and Robert A Weinberg and Paul Fanning and Michael Klagsbrun},
  journal={Journal of cellular biochemistry},
  year={1989},
  volume={39 1},
  pages={13-23}
}
Basic fibroblast growth factor (bFGF) is found in a variety of cells and tissues. We have previously shown that bFGF is a transforming growth factor, but only when fused to a signal peptide (sp-bFGF). Cells expressing the native bFGF are tumorigenic in nude mice only, where the tumors form at a low frequency and grow very slowly as compared to sp-bFGF… CONTINUE READING