Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2.
@article{Bttger2006CharacterizationOT, title={Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2.}, author={Pernille B{\o}ttger and Susanne E. Hede and Morten Grunnet and Boy. Hoyer and Dan Arne Klaerke and Lene Juul Pedersen}, journal={American journal of physiology. Cell physiology}, year={2006}, volume={291 6}, pages={ C1377-87 } }
The general phosphate need in mammalian cells is accommodated by members of the P(i) transport (PiT) family (SLC20), which use either Na(+) or H(+) to mediate inorganic phosphate (P(i)) symport. The mammalian PiT paralogs PiT1 and PiT2 are Na(+)-dependent P(i) (NaP(i)) transporters and are exploited by a group of retroviruses for cell entry. Human PiT1 and PiT2 were characterized by expression in Xenopus laevis oocytes with (32)P(i) as a traceable P(i) source. For PiT1, the Michaelis-Menten…
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