Characterization of transgenic mice with neuron-specific expression of soluble epoxide hydrolase.

@article{Bianco2009CharacterizationOT,
  title={Characterization of transgenic mice with neuron-specific expression of soluble epoxide hydrolase.},
  author={Robert A Bianco and Khristofor Agassandian and Martin D. Cassell and Arthur A. Spector and Curt D. Sigmund},
  journal={Brain research},
  year={2009},
  volume={1291},
  pages={60-72}
}
Soluble epoxide hydrolase (sEH) is the major enzyme responsible for the metabolism and inactivation of epoxyeicosatrienoic acids (EETs). EETs are produced by the cytochrome P450 (CYP) epoxygenase pathway of arachidonic acid (AA) metabolism and tend to be anti-hypertensive, anti-inflammatory and protective against ischemic injury. Since the metabolism of EETs by sEH reduces or eliminates their bioactivity, inhibition of sEH has become a therapeutic strategy for hypertension and inflammation. sEH… CONTINUE READING

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