Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis

@article{Moignard2013CharacterizationOT,
  title={Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis},
  author={Victoria Moignard and Iain Macaulay and Gemma Swiers and Florian Buettner and Judith Sch{\"u}tte and Fernando J. Calero-Nieto and Sarah Kinston and Anagha Joshi and Rebecca Hannah and Fabian J. Theis and Sten Eirik W Jacobsen and Marella F. T. R. de Bruijn and Berthold G{\"o}ttgens},
  journal={Nature Cell Biology},
  year={2013},
  volume={15},
  pages={544-544}
}
Cellular decision-making is mediated by a complex interplay of external stimuli with the intracellular environment, in particular transcription factor regulatory networks. Here we have determined the expression of a network of 18 key haematopoietic transcription factors (TFs) in 597 single primary blood stem and progenitor cells isolated from mouse bone marrow. We demonstrate that different stem/progenitor populations are characterised by distinctive TF expression states, and through… CONTINUE READING
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