Characterization of three HLA-DR beta genes isolated from an HLA-DR 3/4 insulin-dependent diabetic patient

@article{Owerbach2004CharacterizationOT,
  title={Characterization of three HLA-DR beta genes isolated from an HLA-DR 3/4 insulin-dependent diabetic patient},
  author={D. Owerbach and C. Rich and K. Taneja},
  journal={Immunogenetics},
  year={2004},
  volume={24},
  pages={41-46}
}
Three HLA-DRβ genes were isolated from a Swedish HLA-DR3/4 insulin-dependent diabetes mellitus (IDDM) patient and characterized by restriction endonuclease mapping and nucleotide sequence analysis. Two out of the three DNA sequences differed from those of published DRβ-chain sequences. A DRβ-gene probe prepared from exon 4 and flanking sequences was used in a Southern blot analysis of blood donors' DNA and DNA from HLA-DR3/4 IDDM patients and HLA-DR-matched healthy control subjects. This probe… Expand

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