Characterization of the xenobiotic response of Caenorhabditis elegans to the anthelmintic drug albendazole and the identification of novel drug glucoside metabolites.

@article{Laing2010CharacterizationOT,
  title={Characterization of the xenobiotic response of Caenorhabditis elegans to the anthelmintic drug albendazole and the identification of novel drug glucoside metabolites.},
  author={Steven T. Laing and Alasdair C. Ivens and Roz Laing and Sai P. Ravikumar and Victoria Butler and Debra J. Woods and John S. Gilleard},
  journal={The Biochemical journal},
  year={2010},
  volume={432 3},
  pages={
          505-14
        }
}
Knowledge of how anthelmintics are metabolized and excreted in nematodes is an integral part of understanding the factors that determine their potency, spectrum of activity and for investigating mechanisms of resistance. Although there is remarkably little information on these processes in nematodes, it is often suggested that they are of minimal importance for the major anthelmintic drugs. Consequently, we have investigated how the model nematode Caenorhabditis elegans responds to and… CONTINUE READING

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