Characterization of the usage of the serine metabolic network in human cancer.

@article{Mehrmohamadi2014CharacterizationOT,
  title={Characterization of the usage of the serine metabolic network in human cancer.},
  author={Mahya Mehrmohamadi and Xiaojing Liu and Alexander A. Shestov and Jason W. Locasale},
  journal={Cell reports},
  year={2014},
  volume={9 4},
  pages={1507-19}
}
The serine, glycine, one-carbon (SGOC) metabolic network is implicated in cancer pathogenesis, but its general functions are unknown. We carried out a computational reconstruction of the SGOC network and then characterized its expression across thousands of cancer tissues. Pathways including methylation and redox metabolism exhibited heterogeneous expression indicating a strong context dependency of their usage in tumors. From an analysis of coexpression, simultaneous up- or downregulation of… CONTINUE READING
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