Characterization of the translocation-competent complex between the Helicobacter pylori oncogenic protein CagA and the accessory protein CagF.

@article{Bonsor2013CharacterizationOT,
  title={Characterization of the translocation-competent complex between the Helicobacter pylori oncogenic protein CagA and the accessory protein CagF.},
  author={Daniel A. Bonsor and Evelyn Weiss and Anat Iosub-Amir and Tali H. Reingewertz and Tiffany W Chen and Rainer Haas and Assaf Friedler and Wolfgang Fischer and Eric J Sundberg},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 46},
  pages={32897-909}
}
CagA is a virulence factor that Helicobacter pylori inject into gastric epithelial cells through a type IV secretion system where it can cause gastric adenocarcinoma. Translocation is dependent on the presence of secretion signals found in both the N- and C-terminal domains of CagA and an interaction with the accessory protein CagF. However, the molecular basis of this essential protein-protein interaction is not fully understood. Herein we report, using isothermal titration calorimetry, that… CONTINUE READING
4 Citations
40 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Determination of the molecular weight of proteins in solution from a single small-angle x-ray scattering measurement on a relative scale

  • H. Fischer, M. de Oliveira Neto, H. B. Napolitano, I. Polikarpov, A. F. Craievich
  • J. Appl. Crystallogr
  • 2010

Similar Papers

Loading similar papers…