Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction.

Abstract

The thiazide-sensitive Na(+)-Cl(-) cotransporter (TSC) is the major pathway for salt reabsorption in the apical membrane of the mammalian distal convoluted tubule. When expressed in Xenopus laevis oocytes, rat TSC exhibits high affinity for both cotransported ions, with the Michaelis-Menten constant (K(m)) for Na(+) of 7.6 +/- 1.6 mM and for Cl(-) of 6.3… (More)

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@article{Monroy2000CharacterizationOT, title={Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction.}, author={Alberto Alonso Monroy and C. Aguilar-de Plata and Steven C. Hebert and Gerardo Gamba}, journal={American journal of physiology. Renal physiology}, year={2000}, volume={279 1}, pages={F161-9} }