Characterization of the survival effect of tumour necrosis factor-α in human neutrophils

@inproceedings{Walmsley2004CharacterizationOT,
  title={Characterization of the survival effect of tumour necrosis factor-α in human neutrophils},
  author={Sarah R Walmsley and Andrew S. Cowburn and Anastasia Sobolewski and Joanna Murray and Neda Farahi and Ian Sabroe and Edwin R Chilvers},
  year={2004}
}
Granulocyte apoptosis has been proposed as a fundamental, injury-limiting granulocyte-clearance mechanism. As such, inhibition of this process may prevent the resolution of inflammation. Our previous studies have shown that TNFα (tumour necrosis factor-α) has a bi-modal influence on the rate of constitutive neutrophil apoptosis in vitro, causing early acceleration and late inhibition of this process. The pro-apoptotic effect is uniquely TNFR1 (TNF receptor 1) and TNFR2-dependent and the latter… CONTINUE READING