Characterization of the structure and variability of an internal region of hepatitis C virus RNA for M1 RNA guide sequence ribozyme targeting.

@article{Nadal2003CharacterizationOT,
  title={Characterization of the structure and variability of an internal region of hepatitis C virus RNA for M1 RNA guide sequence ribozyme targeting.},
  author={Anna Nadal and H. D. Robertson and Jaime Guardia and Jordi G{\'o}mez},
  journal={The Journal of general virology},
  year={2003},
  volume={84 Pt 6},
  pages={
          1545-8
        }
}
Accessibility to folded RNA and low potential of variation in the target RNA are crucial requirements for ribozyme therapy against virus infections. In hepatitis C virus (HCV), the sequence of the 5'UTR is conserved but the highly folded RNA structure severely limits the number of accessible sites. To expand investigation of targeting in the HCV genome, we have considered an internal genomic region whose sequence variation has been widely investigated and which has a particularly conserved RNA… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 12 references

Specific cleavage of hepatitis C virus RNA genome by human RNase P.

The Journal of biological chemistry • 2002
View 5 Excerpts
Highly Influenced

Effective inhibition of human cytomegalovirus gene expression and replication by a ribozyme derived from the catalytic RNA subunit of RNase P from Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America • 2000
View 3 Excerpts
Highly Influenced

Origin and evolution of viruses.

Transactions of the Royal Society of Tropical Medicine and Hygiene • 1960
View 3 Excerpts
Highly Influenced