Characterization of the structure and reactions of free radicals from serotonin and related indoles.

@article{PerezReyes1981CharacterizationOT,
  title={Characterization of the structure and reactions of free radicals from serotonin and related indoles.},
  author={Edward Perez-Reyes and Ronald Paul Mason},
  journal={The Journal of biological chemistry},
  year={1981},
  volume={256 5},
  pages={2427-32}
}
The ESR spectra of the free radicals formed by the autoxidation of serotonin, 5-hydroxyindole, and 5-hydroxytryptophan in 1 N NaOH are presented. The analysis of the hyperfine splitting constants in H2O and D2O characterize these free radicals as semiquinone-imines, the one-electron oxidation product of the corresponding indole. At alkaline pH, autoxidation of these compounds ultimately leads to solid precipitate and unresolved ESR spectra characteristic of polymeric material. The reduction of… CONTINUE READING

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