Characterization of the steric defense of the HIV-1 gp41 N-trimer region.

Abstract

During viral entry, HIV gp41 adopts a transient conformation called the "prehairpin intermediate" in which a highly conserved therapeutic target, the N-trimer, is exposed. Despite extensive discovery efforts, potent and broadly neutralizing antibodies that target the N-trimer are elusive. We previously demonstrated the N-trimer is protected by a steric… (More)
DOI: 10.1110/ps.038273.108

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Cite this paper

@article{Eckert2008CharacterizationOT, title={Characterization of the steric defense of the HIV-1 gp41 N-trimer region.}, author={Debra M. Eckert and Yu Shi and Sunghwan Kim and Brett Welch and Eunchai Kang and Emily S Poff and Michael S. Kay}, journal={Protein science : a publication of the Protein Society}, year={2008}, volume={17 12}, pages={2091-100} }