Characterization of the split ends-like gene spenito reveals functional antagonism between SPOC family members during Drosophila eye development.

@article{Jemc2006CharacterizationOT,
  title={Characterization of the split ends-like gene spenito reveals functional antagonism between SPOC family members during Drosophila eye development.},
  author={Jennifer Jemc and Ilaria Rebay},
  journal={Genetics},
  year={2006},
  volume={173 1},
  pages={279-86}
}
The novel family of SPOC domain proteins is composed of broadly conserved nuclear factors that fall into two subclasses, termed large and small, based on protein size. Members of the large subgroup, which includes Drosophila SPEN and human SHARP, have been characterized as transcriptional corepressors acting downstream of a variety of essential cell signaling pathways, while those of the small subclass have remained largely unstudied. Since SPEN has been implicated in Drosophila eye development… CONTINUE READING